A cytosine·cytosine base paired parallel DNA double helix with thymine·thymine bulges

FEBS Letters

Gupta, G.¹  Sarma, R.H.¹  Sarma, M.H.¹ 

[1] Institute of Biomolecular Stereodynamics, State University of New York at Albany, Albany, NY 12222, USA

关键词: 1H-NMR 2D-NOESY Oligonucleotide structure;   

DOI  :  10.1016/0014-5793(86)80902-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

500 MHz ¹H NMR studies using 2D-NOESY indicate that the oligonucleotide d(CTCTCT) at low pH forms a parallel double helix with cytosine·cytosine base pairs and thymine·thymine bulges. This unusual structure may explain the hypersensitivity of S₁ nuclease at low pH towards supercoiled plasmids containing d(CT) _n inserts.

【 授权许可】

Unknown