Distinct physiological roles of animal succinate thiokinases Association of guanine nucleotide‐linked succinate thiokinase with ketone body utilization

FEBS Letters

Weitzman, P.D.J.¹  Jenkins, T.M.¹ 

[1] Department of Biochemistry, University of Bath, Bath BA2 7AY, England

关键词: Succinate thiokinase Guanine nucleotide Diabetes Streptozotocin Ketone body utilization (Brain) Metabolism;   

DOI  :  10.1016/0014-5793(86)80900-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two distinct succinate thiokinases have recently been shown to exist in animal tissues, one specific for guanine nucleotide and the other for adenine nucleotide. Their physiological roles have here been investigated by comparing the levels of the two enzymes in liver and brain of normal and diabetic rats. A marked rise in the level of brain guanine nucleotide-linked succinate thiokinase in the diabetic condition is consistent with an enhanced utilization of ketone bodies and hence with the associated elevated demand for succinyl-CoA for the activation of acetoacetate. Taken together with the reported mitochondrial values of the ATP/ADP and GTP/GDP ratios, the results are interpreted to indicate that the adenine nucleotide-linked enzyme functions as a component of the citric add cycle whereas the guanine nucleotide-linked enzyme functions in the opposite metabolic direction to produce succinyl-CoA from succinate.

【 授权许可】

Unknown