Translational regulation of ornithine decarboxylase by polyamines

FEBS Letters

Heby, Olle¹  Persson, Lo¹  Holm, Ingvar¹ 

[1] Departments of Physiology and Zoophysiology, University of Lund, S-223 62 Lund, Sweden

关键词: Ornithine decarboxylase Translational regulation Polyamine Putrescine Spermidine;   

DOI  :  10.1016/0014-5793(86)80892-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, is dramatically increased in proliferating cells. In addition to transcriptional regulation of ODC, the present study shows that the enzyme is regulated at the translational level by putrescine and spermidine. ODC synthesis is inhibited by an increase and stimulated by a decrease in their cellular content. Spermidine is a more potent negative regulator than is putrescine. The effects of polyamines on ODC synthesis were not attributable to changes in the cellular content of ODC mRNA, thus demonstrating regulation at the translational level.

【 授权许可】

Unknown