A new vitamin E analogue more active than α‐tocopherol in the rat curative myopathy bioassay

FEBS Letters

Hughes, L.¹  Burton, G.W.¹  Foster, D.O.²  Zuker, M.²  Slaby, M.¹  Ingold, K.U.¹  Lacelle, S.²  Lusztyk, E.¹ 

[1] Divisions of Chemistry, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario K1A OR6, Canada;Divisions of Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario K1A OR6, Canada

关键词: Vitamin E potency;    Benzofuran analog;    Pyruvate kinase;    Myopathy bioassay;   

DOI  :  10.1016/0014-5793(86)80877-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Vitamin E owes its biological effects to its antioxidant activity. Kinetic and mechanistic studies on phenolic antioxidants in vitro have led us to design and synthesize all-rac-2,4,6,7-tetramethyl-2-(4',8',12'-trimethyltridecyl)-5-hydroxy-3,4-dihydrobenzofuran, 3. In the rat curative myopathy bioassay the acetate of this compound has 1.5–1.9 times the bioactivity of all-rac-α-tocopherol acetate. This represents the first time that a rationally designed synthetic ‘vitamin’ has been found to have more activity in vivo than the corresponding natural vitamin.

【 授权许可】

Unknown