Control of energy metabolism by glucagon and adrenaline in perfused rat liver

FEBS Letters

Soboll, Sibylle¹  Scholz, Roland² 

[1] Institut für Physiologische Chemie I, Universität Düsseldorf, Moorenstr. 5, D-4000 Düsseldorf 1 FRG;Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie, Universität München, München, FRG

关键词: Suhcellular distribution;    Adenine nucleotide;    Proton gradient;    (Perfused rat liver);    Glucagon;    Adrenaline;    Ca2+ effect;   

DOI  :  10.1016/0014-5793(86)80875-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Changes in subcellular distribution of adenine nucleotides, mitochondrial/cytosolic proton gradients, rates of respiration, gluconeogenesis (fasted state) and glycogenolysis (fed state) were studied in isolated perfused rat livers following addition of glucagon (10⁻⁸ M) or adrenaline (10⁻⁷ M). Glucagon increased the gradient in all states. The cytosolic ATP/ADP ratio was increased in the fasted but decreased in the fed state which is consistent with a diminished futile cycling in gluconeogenesis (fasted state) or a decreased glycolytic rate (fed state). Adrenaline caused an increase in the proton gradient and the mitochondrial ATP/ADP ratio. The two effects are attributed to increased calcium entry into the matrix space.

【 授权许可】

Unknown