A surface NAD‐glycohydrolase of human platelets may influence their aggregation

FEBS Letters

Di Giulio, S.¹  Menichelli, A.¹  Mancuso, G.¹  Finazzi-Agrò, A.¹  Del Principe, D.¹  Casini, A.¹ 

[1] Dept of Pediatrics, II University of Rome, Via O. Raimondo, 00173 Rome, Italy

关键词: (Human platelet);    Platelet function;    NADase;    Enzyme activity;   

DOI  :  10.1016/0014-5793(86)80867-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human platelets may hydrolyze externally added NAD⁺ yielding ADPR and nicotinamide. The extent of hydrolysis is significantly higher when the platelets are stimulated. The presence of external NAD⁺ strongly inhibits the aggregation induced by every agonist used. It seems that adenosine or ADPR itself generated by NAD⁺ hydrolysis may be responsible for the inhibition of aggregation. Evidence is given that some of the NAD⁺ hydrolysis product is taken up by stimulated platelets.

【 授权许可】

Unknown