Pertussis toxin blocks angiotensin II‐induced calcium influx but not inositol trisphosphate production in adrenal glomerulosa cell

FEBS Letters

Shibata, Hiroshi¹  Kojima, Itaru¹  Ogata, Etsuro¹ 

[1] The Fourth Department of Internal Medicine, University of Tokyo School of Medicine, 3-28-6 Mejirodai, Bunkyo-ku, Tokyo 112, Japan

关键词: Angiotensin II (Adrenal glomerulosa cell) Ca2+ influx Pertussis toxin Inositol trisphosphate;   

DOI  :  10.1016/0014-5793(86)80841-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Involvement of GTP-binding proteins in angiotensin II-induced mobilization of calcium has been examined in adrenal glomerulosa cells by using pertussis toxin. Pretreatment of glomerulosa cells with pertussis toxin abolishes angiotensin II-induced calcium influx without blocking inositol trisphosphate production. These results suggest a role of the pertussis toxin-sensitive GTP-binding protein in transducing angiotensin II-receptor occupancy into opening of calcium channel.

【 授权许可】

Unknown