The involvement of calcium in the stimulation of respiration in isolated rat hepatocytes by adrenergic agonists and glucagon

FEBS Letters

Crompton, Martin¹  Goldstone, Timothy P.¹ 

[1] Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, England

关键词: Respiration Glucagon cytosolic Ca2+Phenylephrine Isoprenaline Hepatocyte;   

DOI  :  10.1016/0014-5793(86)80811-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of adrenergic agonists and glucagon on respiration and cytosolic free Ca²⁺ measured with quin2, in female rat hepatocytes have been compared. In the presence of lactate, all three agonists caused a permanent stimulation of respiration. However, unlike phenylephrine, glucagon induced only a transient increase in cytosolic free Ca²⁺ and isoprenaline caused no detectable change. Mechanisms other than Ca²⁺ for respiratory stimulation by cAMP-linked agonists in liver are indicated.

【 授权许可】

Unknown