Characteristic anticodon sequences of major tRNA species from an extreme thermophile, Thermus thermophilus HB8

FEBS Letters

Takahashi, Seizo⁴  Watanabe, Kimitsuna²  Watanabe, Tatsuo⁵  Mitamura, Yasue⁴  Miyazawa, Tatsuo⁵  Yokoyama, Shigeyuki⁵  Kitazume, Masako⁴  Hara-Yokoyama, Miki¹  Kuchino, Yoshiyuki³  Morii, Toshie⁴  Nishimura, Susumu³ 

[1] Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan;Biology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104, Japan;Department of Chemistry, Japan Women's University, Bunkyo-ku, Tokyo 112, Japan;Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan

关键词: tRNA Anticodon Codon usage (Thermus thermophilus HB8) Thermophile;   

DOI  :  10.1016/0014-5793(86)80667-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Major species of tRNA^Glu, tRNA^Lys, tRNA^Val, tRNA^Ala, tRNA^Ser and tRNA^Arg were purified from Thermus thermophilus HB8, and their anticodon sequences were found to be CUC, CUU, CAC, GGC, GGA and CCG, respectively, with unmodified G or C as the first letter. These anticodons exactly correspond to the codons as used most frequently among synonymous codons in the structural genes of extreme thermophiles. The stable complexes of these anticodons (in particular, GGN or CCN) with their corresponding codons probably contribute to the correct protein biosynthesis in extreme thermophiles at high temperature.

【 授权许可】

Unknown