A new hydrophobic anchor for the attachment of proteins to liposomal membranes

FEBS Letters

Weissig, V.²  Lasch, J.²  Torchilin, V.P.¹  Klibanov, A.L.¹ 

[1] USSR Cardiology Research Center, Academy of Medical Sciences, 3rd Cherepkovskaja 15 A, 121552 Moscow, USSR;Institute of Biochemistry, Martin-Luther-University Halle/Saale, Hollystrasse 1, PSF 184, DDR-4020 Halle, GDR

关键词: Liposome Phosphatidylethanolamine Immobilization α-Chymotrypsin Liposome targeting;    PE-phosphatidylethanolamine;    PC;    phosphatidylcholine;    DPPC;    dipalmitoylphosphatidylcholine;    α-CT;    α-chymotrypsin;    DMSO;    dimethyl sulfoxide;    ATEE;    N-acetyl-L-tyrosine ethyl ester;   

DOI  :  10.1016/0014-5793(86)80654-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The model enzyme α-chymotrypsin covalently modified by a phosphatidylethanolamine derivative has been attached to liposomal membranes in high yield. A maximal protein/lipid ratio of 5.4 × 10⁻³ mol lipid was achieved.

【 授权许可】

Unknown