Oxygen dependence of vitamin K‐dependent carboxylase and vitamin K epoxidase

FEBS Letters

McTigue, John J.¹  Suttie, J.W.¹ 

[1]Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA

关键词: Vitamin K Oxygen Carboxylation Epoxidation γ-Carboxyglutamic acid;   

DOI  :  10.1016/0014-5793(86)80513-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A study of the oxygen requirements of the rat liver microsomal vitamin K-dependent carboxylase and vitamin K 2,3-epoxidase indicated that both enzymes had a K _m for O₂ in the range 60–80 μM. This value was not influenced by vitamin concentration, alterations in carboxylase substrate, Mn²⁺, or dithiothreitol, and is consistent with the hypothesis that both activities are catalyzed by the same enzyme.

【 授权许可】

Unknown