期刊论文详细信息
FEBS Letters | |
Enhancement in anti‐Semliki Forest virus activity of ds RNA by a muramyl dipeptide | |
Jain, R.K.1  George, C.X.1  Gupta, C.M.1  Anand, Nitya1  | |
[1] Divisions of Biochemistry, Medicinal Chemistry and Microbiology, Central Drug Research Institute, Lucknow 226 001, India | |
关键词: Viral infection Interferon inducer Muramyl dipeptide Macrophage activation; SFV; Semliki Forest virus; VSV; vesicular stomatitis virus; PMDP; N-palmitoylmuramyl-L-alanyI-D-isoglutamine; MDP; N-acetylmuramyl-L-alanyl-D-isoglutamine; PBS; phosphate-buffered saline (pH 7.2); | |
DOI : 10.1016/0014-5793(86)80506-3 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Antiviral activity of an interferon-inducing mycoviral ds RNA against Semliki Forest virus infection was considerably enhanced by N-palmitoylmuramyl-L-alanyl-D-isoglutamine (PMDP), a new muramyl dipeptide. This enhancement in activity was not due to increased production of interferon, but resulted probably from a PMDP-induced increase in nonspecific resistance to infection. These results indicate that a combined treatment with an interferon inducer and muramyl dipeptide may prove highly useful to control effectively viral infections.
【 授权许可】
Unknown
【 预 览 】
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