Enhancement in anti‐Semliki Forest virus activity of ds RNA by a muramyl dipeptide

FEBS Letters

Jain, R.K.¹  George, C.X.¹  Gupta, C.M.¹  Anand, Nitya¹ 

[1] Divisions of Biochemistry, Medicinal Chemistry and Microbiology, Central Drug Research Institute, Lucknow 226 001, India

关键词: Viral infection Interferon inducer Muramyl dipeptide Macrophage activation;    SFV;    Semliki Forest virus;    VSV;    vesicular stomatitis virus;    PMDP;    N-palmitoylmuramyl-L-alanyI-D-isoglutamine;    MDP;    N-acetylmuramyl-L-alanyl-D-isoglutamine;    PBS;    phosphate-buffered saline (pH 7.2);   

DOI  :  10.1016/0014-5793(86)80506-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Antiviral activity of an interferon-inducing mycoviral ds RNA against Semliki Forest virus infection was considerably enhanced by N-palmitoylmuramyl-L-alanyl-D-isoglutamine (PMDP), a new muramyl dipeptide. This enhancement in activity was not due to increased production of interferon, but resulted probably from a PMDP-induced increase in nonspecific resistance to infection. These results indicate that a combined treatment with an interferon inducer and muramyl dipeptide may prove highly useful to control effectively viral infections.

【 授权许可】

Unknown