FEBS Letters | |
Creutzfeldt‐Jakob infection increases adenylate cyclase activity in specific regions of guinea pig brain | |
Manuelidis, Laura2  Manuelidis, Elias E.2  Valley, Susan2  Rasenick, Mark M.1  | |
[1] Deparment of Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL 60680 USA;Section of Neuropathology, Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA | |
关键词: GTP-binding protein; Receptor-effector coupling; Oncogene product; Dementia; Signal transduction; | |
DOI : 10.1016/0014-5793(86)81205-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Creutzfeldt-Jakob disease is a slow, infectious, progressive neurological disorder which results in human dementia. Synaptic membranes from various brain regions of guinea pigs infected with Creutzfeldt-Jakob disease show increased guanyl nucleotide- or 5-hydroxytryptamine-mediated activation of adenylate cyclase. This increased enzyme activity appears due, primarily, to facilitated ‘coupling’ between the GTP-binding protein which stimulates adenylate cyclase (GNs) and the catalytic moiety of that enzyme rather than increased sensitivity to 5-hydroxytryptamine. It is possible that this phenomenon is due to direct effects of the Creutzfeldt-Jakob infectious agent, or a pathological product resulting from that agent, upon synaptic membrane adenylate cyclase.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020287838ZK.pdf | 560KB | download |