Maitotoxin stimulat es the formation of inositol phosphates in rat aortic myocytes

FEBS Letters

Berta, Philippe²  Travo, Pierre¹  Derancourt, Jean²  Sladeczek, Fritz⁴  Durand, Monique³  Haiech, Jacques² 

[1] Laboratoire de Pharmacodynamique CNRS ERA 787, Faculté de Pharmacie, Université Louis Pasteur BP 10, 67048 Strasbourg Cedex, France;Centre de recherches de Biochimie Macromoléculaire LP8402 et INSERM Unité 249, BP 5051, Cedex, France;Laboratoire de Cytophysiologie végétale et de Toxicologie cellulaire. Université de Paris VII, 75251 Paris Cedex 05 France;Centre CNRS-INSERM de Pharmacologie-Endocrinologie, BP 5055, 34033 Montpellier CedexFrance

关键词: Maitotoxin;    Polyphosphoinositide Myocyte (Rat aorta);    CTX;    ciguatoxin;    MTX;    maitotoxin;    VSCC;    voltage-sensitive calcium channel;    IP1;    IP2;    IP3;    the mono-;    bis- and trisphosphates of inositol;    IP;    inositol phosphate;   

DOI  :  10.1016/0014-5793(86)80355-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Maitotoxin is the most potent of the known marine toxins. The effect of maitotoxin on muscle contraction or hormone release was consistent with its action on the voltage-sensitive channel. Indeed, calcium antagonists such as nifedipine or diltiazem were able to reverse the maitotoxin effects. Using smooth muscle cells, we have analysed the effects of maitotoxin on the inositol phosphate metabolism. Maitotoxin stimulates the inositol phosphate formation (5 ± 1.8-fold in the presence of 10 mM LiCI). Moreover, this effect is not reversed, even partially by calcium antagonists, by α₁ antagonists and is not mimicked by Ca²⁺ ionophores such as A23187 or calcium agonists such as Bay-K 8644. The action of maitotoxin is further discussed in this paper.

【 授权许可】

Unknown