C‐ras H and ornithine decarboxylase are induced by oestradiol‐17β in the mouse uterine luminal epithelium independently of the proliferative status of the cell

FEBS Letters

Cheng, Shirley V.Y.¹  Pollard, Jeffrey W.¹ 

[1] MRC Group in Human Genetic Diseases, Department of Biochemistry, King's College, Campden Hill, London W8 7AH, England

关键词: Estradiol-17β Progesterone Ornithine decarboxylase Proto-oncogene;   

DOI  :  10.1016/0014-5793(86)80269-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Oestradiol-17 β (E₂) treatment of the ovariectomized mouse results in a synchronised wave of cell proliferation in the uterine luminal epithelium. At the peak of DNA synthesis the mRNA level of the c-ras ^H protooncogene and ornithine decarboxylase were significantly increased. Progesterone treatment completely inhibits the E₂ induced wave of DNA synthesis but does not greatly influence the level of these 2 mRNAs. Thus in the uterine luminal epithelium E₂ regulates the level of ornithine decarboxylase and c-ras ^H independently of cell proliferation.

【 授权许可】

Unknown