Identification of a c‐myc oncogene lacking the exon 1 in the normal cells of a patient carrying a thyroid carcinoma

FEBS Letters

Gambari, R.¹  Barbieri, R.¹  Buzzoni, D.¹  Patracchini, P.¹  Rossi, M.¹  Uberti, E.Degli¹  Conconi, F.¹  Del Senno, L.¹  Marchetti, G.¹  Rossi, P.¹  Bernardi, F.¹ 

[1] Centro di Studi Biochimici sul Morbo di Cooley and Clinica Medica, Universitá degli Studi, Via L. Borsari 46, 44100 Ferrara, Italy

关键词: c-myc oncogene DNA alteration RNA level Neoplastic transformation;   

DOI  :  10.1016/0014-5793(86)80266-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In this paper we describe an alteration of the c-myc oncogene present in the white blood cells and normal as well as neoplastic thyroid cells of a subject carrying a thyroid carcinoma. Restriction enzyme mapping and hybridization to human c-myc probes specific for different regions of this gene demonstrate that this subject carries, in addition to the normal one, a c-myc oncogene lacking the first exon and part of the first intron. The levels of the c-myc mRNA in thyroid cells of this subject do not show differences with respect to thyroid cells from other subjects. Taken together, these findings indicate that the deletion of the first exon of the c-myc oncogene, in itself, does not produce overtranscription of this oncogene nor hematopoietic malignancies.

【 授权许可】

Unknown