Chemical characterization and opioid activity of an exorphin isolated from in vivo digests of casein

FEBS Letters

Meisel, Hans¹ 

[1] Institut für Chemie und Physik der Bundesanstalt für Milchforschung, 2300 Kiel, FRG

关键词: Exorphin Casomorphin β-Casein (Duodenal digest) Opioid activity;   

DOI  :  10.1016/0014-5793(86)80251-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The in vivo formation of an opioid peptide (exorphin) derived from β-casein has been proved for the first time. It was isolated from duodenal chyme of minipigs after feeding with the milk protein casein. The exorphin has been identified as a β-casein fragment by end-group determinations and qualitative amino acid analysis of the purified peptide. This peptide, named β-casomorphin-11, displayed substantial opioid activity in an opiate receptor-binding assay.

【 授权许可】

Unknown