Intracellular Ca2+‐calmodulin system involved in the palytoxin‐induced K+ release from rabbit erythrocytes

FEBS Letters

Karaki, Hideaki¹  Nagase, Hiromi¹  Ozaki, Hiroshi¹  Urakawa, Norimoto¹ 

[1] Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan

关键词: Palytoxin K+ release Ca2+ Calmodulin;   

DOI  :  10.1016/0014-5793(86)80145-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Palytoxin (PTX) caused K⁺ release from rabbit erythrocytes which was dependent on the concentrations of extracellular Ca²⁺ and PTX. In a Ca²⁺-free solution, PTX still caused a slow K⁺ release. An intracellular Ca²⁺ antagonist, TMB-8, an intracellular Ca²⁺ chelator, quin 2, and calmodulin inhibitors, prenylamine, W-7 and W-5, inhibited the PTX-induced K⁺ release in a Ca²⁺-free solution. These results suggest that the PTX-induced K⁺ release is dependent on the process including intracellular Ca²⁺ and calmodulin.

【 授权许可】

Unknown