Bleomycin‐detectable iron in plasma from Plasmodium vinckei vinckei‐infecied mice

FEBS Letters

Buffinton, G.D.¹  Cowden, W.B.¹  Hunt, N.H.¹  Clark, I.A.² 

[1] Departments of Experimental Pathology, John Curtin School of Medical Research, Canberra, ACT 2601, Australia;Department of Zoology, Faculty of Science, Australian National University, Canberra, ACT 2601, Australia

关键词: Malaria Bleomycin Iron detection Free radical Tissue damage;   

DOI  :  10.1016/0014-5793(86)80131-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

(1) Plasma from mice heavily parasitized by Plasmodium vinckei vinckei was found to contain micromolar levels of iron as detected by the ‘bleomycin assay’ (slightly modified) of Gutteridge et al. [(1981) Biochem. J. 199, 263-265]. Uninfected mouse plasma contained little or no bleomycin-detectable iron. (2) Plasma ultrafiltrate from infected mice contained no bleomycin-detectable iron, indicating that such iron was associated with the protein/macromolecule fraction. (3) We speculate that this iron could catalyse reduction of peroxides in vivo and thus play a role in malaria pathology.

【 授权许可】

Unknown