The heparin‐binding site(s) of histidine‐rich glycoprotein as suggested by sequence homology with antithrombin III

FEBS Letters

Odani, Shoji¹  Koide, Takehiko²  Foster, Donald² 

[1] Department of Biochemistry, Niigata University School of Medicine, Niigata 951, Japan;Department of Biochemistry, University of Washington, Seattle, WA 98195, USA

关键词: Histidine-rich glycoprotein;    Antithrombin III;    Heparin;    Heparin-binding site;    Sequence homology;   

DOI  :  10.1016/0014-5793(86)80092-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A high degree of sequence homology has been found between the N-terminal region of histidine-rich glycoprotein (HRG) and that of antithrombin III (AT III) where the putative heparin-binding site of AT HI is located. The amino acid residue at the position corresponding to Arg-47 of AT III that is essential for the heparin-binding was also arginine (Arg 23 and 78) in the homologous sequences of HRG. These observations strongly suggest that the heparin-binding sites of HRG and AT III are evolutionarily related. There was no apparent sequence similarity between the remaining about 70% portions of the two proteins.

【 授权许可】

Unknown