Control of protein synthesis by amino acid supply

FEBS Letters

Thomas, Huw D.J.¹  Arnstein, Henry R.V.¹  Lange, Jeremy D.¹  Barwick, Carl W.¹ 

[1] Department of Biochemistry, King's College London, Strand, London WC2R2LS, England

关键词: Asparaginase Protein synthesis Asparagine deprivation mRNA translation;   

DOI  :  10.1016/0014-5793(86)80066-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The enzyme asparaginase, which hydrolyses asparagine to aspartic acid, inhibited cell-free protein synthesis by reticulocyte lysates. The inhibition was rapid and complete when sufficient enzyme was added but could be prevented or reversed by the addition of asparagine. The initial effect of asparaginase appears to be a block in polypeptide chain elongation due to asparagine deprivation, but there are some indications that prolonged incubation under these conditions may give rise to a secondary decrease in initiation of protein synthesis.

【 授权许可】

Unknown