High enkephalyl peptide degradation, due to angiotensin‐converting enzyme‐like activity in human CSF

FEBS Letters

Lantz, I.¹  Terenius, L.¹ 

[1] Uppsala University, Dept of Pharmacology, Box 591, S-751 24 Uppsala, Sweden

关键词: (Cerebrospinal fluid);    Enkephalin peptide Degradation rate;    Angiotensin-converting enzyme;    Enzyme inhibitor;    HPLC;   

DOI  :  10.1016/0014-5793(85)80073-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The metabolism of enkephalin peptides was studied in human cerebrospinal fluid. The degradation rates of (Leu)-enkephalin and (Leu)-enkephalin-Arg⁶ were compared and the latter was degraded at a 10-fold higher rate. The major enzyme activity was investigated by M _r determination and inhibition experiments, showing marked similarity with angiotensin-converting enzyme.

【 授权许可】

Unknown