1,4‐Thiomorpholine‐3,5‐dicarboxylic acid, a novel cyclic imino acid detected in bovine brain

FEBS Letters

Pecci, L.¹  Ricci, G.¹  Matarese, R.M.¹  Cavallini, D.¹ 

[1] Istituto di Chimica Biologica, Università di Roma, La Sapienza, Italy

关键词: 1;    4-Thiomorpholine-3;    5-dicarboxylic acid;    Brain;    Cyclic imino acid;    Sulfur compound;    Lanthionine;    TMDA;    1;    4-thiomorpholine-3;    5-dicarboxylic acid;    cyclothionine;    1;    4-hexahydrothiazepine-3;    5-dicarboxylic acid;   

DOI  :  10.1016/0014-5793(85)80117-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Gas-liquid chromatography of enriched bovine brain extract revealed the occurrence of several sulfur-containing compounds. By co-chromatography with authentic product and by mass-spectrometric analysis, one of these compounds has been identified as 1,4-thiomorpholine-3,5-dicarboxylic acid (TMDA). The possible derivation of TMDA from lanthionine is discussed. This represents the second S-containing cyclic imino acid so far discovered in a mammalian brain whose physiological significance has not yet been explored.

【 授权许可】

Unknown