Glyceraldehyde‐3‐phosphate dehydrogenase is one of the three major RNA‐binding proteins of rabbit reticulocytes

FEBS Letters

Ryazanov, Alexei G.¹ 

[1] Institute of Protein Research, Academy of Sciences of the USSR, 142292 Pushchino, Moscow Region, USSR

关键词: Glyceraldehyde-3-phosphate dehydrogenase;    RNA-binding protein;    Polyribosome association;    Glycolysis compartmentation;   

DOI  :  10.1016/0014-5793(85)80058-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

One of the 3 major RNA-binding proteins of rabbit reticulocytes, a polypeptide of 36 kDa, is identified as glyceraldehyde-3-phosphate dehydrogenase (GAPD). This fact was deduced from the identity of molecular masses, one-dimensional peptide maps and isoelectric points of the 36 kDa protein and GAPD from rabbit muscle. It is concluded that GAPD can bind rather unspecifically different RNAs and polynucleotides. This means that GAPD, like other RNA-binding proteins, can form loose dynamic complexes with polyribosomes. Association of such a kind may be used for compartmentation of glycolysis near polyribosomes.

【 授权许可】

Unknown