Caldesmon‐induced inhibition of ATPase activity of actomyosin and contraction of skinned fibres of chicken gizzard smooth muscle

FEBS Letters

Dabrowska, R.²  Szpacenko, A.²  Wagner, J.¹  Rüegg, JC.¹ 

[1] Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, D-6900 Heidelberg, FRG;Department of Muscle Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteur Str., 02-093 Warsaw, Poland

关键词: Caldesmon;    Calmodulin;    ATPase activity;    Skinned fiber;    Chicken gizzard;   

DOI  :  10.1016/0014-5793(85)80032-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Caldesmon induces inhibition of MG²⁺-ATPase activity of actomyosin and relaxation of skinned fibers of chicken gizzard smooth muscle without influencing the level of myosin light chain-1 phosphorylation. Both these effects are reversed by calmodulin at a high molar excess over caldesmon in the presence of Ca²⁺.

【 授权许可】

Unknown