25‐Hydroxyvitamin D3 3‐sulphate is a major circulating form of vitamin D in man

FEBS Letters

Axelson, Magnus¹ 

[1] Department of Clinical Chemistry at Karolinska Hospital, Karolinska Institutet, S-104 01 Stockholm, Sweden

关键词: Vitamin D;    25-Hydroxyvitamin D;    Sterol metabolism;    Steroid conjugation;    Sulfate ester;    Human plasma;   

DOI  :  10.1016/0014-5793(85)80002-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

25-Hydroxyvitamin D₃ 3β-sulphate has been identified in human plasma. The compound was isolated by anion-exchange chromatography and following hydrolysis it was characterized by high-performance liquid chromatography and gas chromatography-mass spectrometry. The mean concentration of sulphated 25-hydroxy vitamin D₃ in plasma from 60 patients was 16.7 ±7.1 and the levels often exceeded those of the corresponding free compound. The study also shows that unconjugated 25-hydroxvitamin D₃ is not readily sulphated by man in vivo.

【 授权许可】

Unknown