Sequence of the OXA2 β‐lactamase: comparison with other penicillin‐reactive enzymes

FEBS Letters

Mossakowska, D.¹  Stephenson, P.¹  Dale, J.W.¹  Godwin, D.¹  Wall, S.¹ 

[1] Department of Microbiology, University of Surrey, Guildford, Surrey GU2 5XH, England

关键词: β-Lactamase;    Penicillin;    Antibiotic resistance;    Resistance plasmid;    DNA sequence;   

DOI  :  10.1016/0014-5793(85)80989-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The nucleotide sequence of the unusual plasmid-mediated OXA2 β-lactamase is presented, and compared with other β-lactamases. The OXA2 enzyme has similar features at the presumed active site, but no other significant regions ofhomology with other penicillin-reactive enzymes. The active site homology may therefore represent convergent evolution of otherwise dissimilar genes.

【 授权许可】

Unknown