Guanine nucleotides and Ca‐dependent exocytosis

FEBS Letters

Knight, D.E.¹  Baker, P.F.¹ 

[1] MRC Secretory Mechanisms Group, Department of Physiology, King's College, Strand, London WC2R2LS, England

关键词: Calcium;    Exocytosis;    GTP-binding protein;    GTP-γ-S;    Phorbol ester;    Protein kinase C;   

DOI  :  10.1016/0014-5793(85)81053-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Exposure of ‘leaky’ adrenal medullary cells to GTP-γ-S inhibits Ca-dependent exocytosis in bovine cells, but stimulates exocytosis in chicken cells. The inhibitory action on bovine cells persists in the presence of TPA suggesting that in this tissue an inhibitory GTP-binding protein may modulate the action of protein kinase C on exocytosis.

【 授权许可】

Unknown