Transient transcriptional inhibition of the transferrin gene by cyclic AMP

FEBS Letters

Levin, Mariano J.²  Brissot, Pierre³  Tuil, David²  Dreyfus, Jean-Claude²  Munnich, Arnold²  Vaulont, Sophie²  Bouton, Marie M.¹  Kahn, Axel²  Moguilewsky, Martine¹ 

[1] Centre de recherches Roussel Uclaf, 93230 Romainville, France;Laboratoire de recherche en génétique et pathologie moléculaires. Unité 129 de l'INSERM, CHU Cochin, 75674 Paris Cedex 14 France;Unité d'étude fonctionnelle des maladies du foie, CHU Rennes, 35033 Rennes Cedex, France

关键词: Transferrin gene;    Transcription;    Cyclic AMP;    Iron overload;    Iron depletion;    Steroid hormone;   

DOI  :  10.1016/0014-5793(85)81046-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transferrin mRNA content and gene transcription rate were measured in the liver of rats submitted to iron overload or depletion, castration, treatment with sexual steroid hormones, glucagon and cyclic AMP. The influence of puberty in males and females and of pregnancy was also analysed. Glucagon and cyclic AMP reduced mRNA level by about 50% at the 12th hour of treatment and transferrin gene transcription by as muchas 95% at the 30th minute of drug infusion, with a secondary increase of the transcription rate for a protracted treatment. None of the other hormones tested had any detectable effect on transferrin gene expression, the same being true for iron overload or depletion.

【 授权许可】

Unknown