A new tool to study genetic expression using 2‐D electrophoresis data: the functional map concept

FEBS Letters

Rabilloud, T.¹  Vincens, P.¹  Tarroux, P.¹ 

[1] UA 686, Ecole Normale Supérieure, Laboratoire de Zoologie, 46 rue d'Ulm, 75005 Paris, France

关键词: Data analysis;    Developmental regulation;    2-D electrophoresis;   

DOI  :  10.1016/0014-5793(85)81018-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A method derived from general computerized data analysis techniques is used here first to tabulate the characteristics of individual peptide spots observed by two-dimensional electrophoresis and to compare these characteristics among spots. Multivariate analysis of such data arrays then leads to the grouping of spots in an n-dimensional space, according to their expression characteristics. Such maps display zones which are characteristic of the tissue studied. These functional maps provide a powerful analytical tool for describing such functional interactions and also for predicting the function of unidentified peptides observed on the electrophoresis gels.

【 授权许可】

Unknown