The primary structure of two polypeptide chains from preparations of homeostatic thymus hormone (HTHα and HTHβ)

FEBS Letters

Zeppezauer, Michael¹  Carlquist, Mats²  Reichhart, Robert³  Jörnvall, Hans³ 

[1] Fachbereich 15.2, Analytische und Biologische Chemie, Universität des Saarlandes, D-6600 Saarbrücken, FRG;Department of Biochemistry II, Karolinska Institutet, S-104 01 Stockholm, Sweden;Department of Chemistry I, Karolinska Institutet, S-104 01 Stockholm, Sweden

关键词: Thymus hormone;    Histone;    Homology;    Amino acid sequence analysis;   

DOI  :  10.1016/0014-5793(85)80875-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The primary structures of the 2 polypeptide chains (HTH_α and HTH_β) of the homeostatic thymus hormone (HTH) were determined. The entire structures were found to be identical to those of histones H2A and H2B, respectively, without evidence for sub-types, proteolytic processings, or other peptide fragments. The results show that suggestions for new extranuclear and hormone-like histone functions apply to HTH preparations with intact protein chains of the H2 histones

【 授权许可】

Unknown