Selective expression of glutathione transferase isoenzymes in chemically induced preneoplastic rat heptocyte nodules

FEBS Letters

Jensson, Helgi¹  Eriksson, Lennart C.²  Mannervik, Bengt¹ 

[1] Department of Biochemistry, Arrhenius Laboratory University of Stockholm, S-106 91 StockholmSweden;Deparment of Pathology, Karolinska Institutet, Huddinge University Hospital, S-141 86 Huddinge, Sweden

关键词: Glutathione transferase Hepatocyte nodule Isoenzyme induction Preneoplastic marker Immunoprecipitation;   

DOI  :  10.1016/0014-5793(85)81225-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Isoenzymes of glutathione transferase were shown to occur at selectively altered levels in rat hepatocyte nodules produced by 2-acetylaminofluorene treatment. Changes were measured by different substrates, antibodies raised against purified glutathione transferases, and by purification of the major isoenzymes. Isoenzymes composed of subunits 1, 2 and 3, expressed in normal liver tissue, all occurred at increased concentrations in nodules, whereas the level of transferase 4-4 was decreased. The most conspicuous change was the appearance of glutathione transferase 7-7 (or transferase P), the concentration of which in negligible in normal liver.

【 授权许可】

Unknown