Two functional domains conserved in major and alternate bacterial sigma factors

FEBS Letters

Stragier, Patrick¹  Bouvier, Jean¹  Parsot, Claude² 

[1] Institut de Microbiologie, Bât 409, Université Paris-Sud, 91405 Orsay Cedex, France;Unité de Biochimie Cellulaire, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France

关键词: Sigma factor RNA polymerase Promoter Escherichia coli Bacillus subtilis;   

DOI  :  10.1016/0014-5793(85)81203-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Sequences of the sigma factors of Escherichia coli and Bacillus subtilis were aligned with the sequences of two sigma-like proteins, HtpR, involved in the expression of heat-shock genes in E. coli, and SpoIIG, necessary for endospore formation in B. subtilis. An internal region is highly conserved in the four proteins and is proposed to be involved in binding of sigma factors to core RNA polymerase. The carboxy-terminal part of the four proteins presents the characteristic structure found in several prokaryotic DNA-binding proteins and is proposed to be involved in promoter recognition.

【 授权许可】

Unknown