B‐Z transition in poly(dG‐dC)·poly(dG‐dC) in the presence of formaldehyde amino derivatives

FEBS Letters

Tyaglov, B.V.²  Permogorov, V.I.²  Poverenny, A.M.¹  Kiseleva, V.I.¹ 

[1] Institute of Medical Radiology, Academy of Medical Sciences of the USSR, Obninsk, Kaluga Region, USSR;All-Union Research Institute of Genetics and Selection of Industrial Microorganism, Moscow, USSR

关键词: B-Z transition;    Circular dichroism;    Poly(dG-dC)·poly(dG-dC);    Formaldehyde Aminomethylolic compound;    Amino derivative;    Glycine;   

DOI  :  10.1016/0014-5793(85)80707-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It was shown by circular dichroism that the B-Z transition of poly(dG-dC)·poly(dG-dC) in high NaCl concentrations occurred more rapidly in the presence of formaldehyde and Tris. The product of formaldehyde and glycine interaction induces changes in the poly(dG-dC)·poly(dG-dC) CD spectral characteristics of a ‘B-like’ conformation. It is supposed that the B-Z transition occurs without large-scale hydrogen bond breakage.

【 授权许可】

Unknown