Product of extracellular‐superoxide dismutase catalysis

FEBS Letters

Marklund, Stefan L.¹ 

[1] Department of Clinical Chemistry, Umeå University Hospital, S-901 85 Umeå, Sweden

关键词: Superoxide dismutase Superoxide radical Oxigen radical Hydrogen peroxide Plasma;   

DOI  :  10.1016/0014-5793(85)80613-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Extracellular-superoxide dismutase is a tetrameric enzyme containing four copper atoms. It has previously been shown to catalyse the decay of the Superoxide radical, but the resulting product was not determined. In a xanthine oxidase-xanthine system in which about 30% of the electron flux resulted in Superoxide radical formation, accumulation of hydrogen peroxide was determined. Catalysis of Superoxide radical decay by extracellular-superoxide dismutase was found to result in hydrogen peroxide formation. The catalysed reaction is thus identical to those of previously investigated Superoxide dismutases. Human manganese superoxide dismutase was also found to dismute the Superoxide radical to hydrogen peroxide and water.

【 授权许可】

Unknown