A proposal for the structure of conotoxin ‐ a potent antagonist of the nicotinic acetylcholine receptor

FEBS Letters

Hider, R.C.¹ 

[1] Department of Chemistry, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, England

关键词: Conidae Conotoxin Neurotoxicity Circular dichroism Secondary structure;   

DOI  :  10.1016/0014-5793(85)80602-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Conotoxin, a thirteen residue neurotoxic peptide, is demonstrated, by circular dichroism measurements, to possess a high content of α-hélix. The location of this helix in the sequence is severely limited by the structural preferences of individual amino acids and by the positioning of the two cystine links. Comparisons are made between the reactive site of elapidae snake venom postsynaptic neurotoxins and the surface of the conotoxin molecule.

【 授权许可】

Unknown