The complete amino acid sequence of the major mammalian neurofilament protein (NF‐L)

FEBS Letters

Weber, Klaus¹  Geisler, Norbert¹  Plessmann, Uwe¹ 

[1] Max Planck Institute for Biophysical Chemistry, D-3400 Goettingen, FRG

关键词: Neurofilament;    Intermediate filament;    Keratin;    Amino acid sequence;    Evolution;    Desmin;   

DOI  :  10.1016/0014-5793(85)80357-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The first complete amino acid sequence of a neurofilament protein has been established. Porcine NF-L contains 548 residues corresponding to a molecular mass of ~62 kDa. This value is noticeably smaller than the 68–72 kDa estimates from gel electrophoresis. Sequence comparison among the 6 non-epithelial intermediate filament (IF) proteins of warm-blooded vertebrates shows that the three NF proteins are the most remote members. Additionally and unexpectedly they reveal among each other lower sequence identity than the three non-neuronal IF proteins GFAP, desmin, and vimentin where the last two are particularly closely related. Certain schemes of IF protein evolution are discussed.

【 授权许可】

Unknown