α‐MSH and neurofilament M‐protein share a continuous epitope but not extended sequences

FEBS Letters

Weber, Klaus¹  Fischer, Stefan¹  Shaw, Gerry¹ 

[1] Max Planck Institute for Biophysical Chemistry, D-3400 Göttingen, FRG

关键词: α-MSH;    Neuropeptide;    Neurofilament;    Neuron;    Epitope;    Crossreactivity;   

DOI  :  10.1016/0014-5793(85)80289-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The long recognized neurofibrillary immunoreactivity of the nervous system with α-MSH antibodies arises from an epitope on neurofilament M-protein which we have now characterized. It is situated in the amino terminal residues where M-protein and α-MSH exhibit similar but not identical sequences. Their divergence past residue 5 precludes a physiological significance of the crossreactivity which seems to have arisen fortuitously. Our results question previous speculations as to the existence of extrapituitary α-MSH-like hormones.

【 授权许可】

Unknown