FEBS Letters | |
Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes | |
Hardie, D.Grahame1  Holland, Ross1  | |
[1] MRC Protein Phosphorylation Group, Biochemistry Department, Dundee University, Medical Sciences Institute, Dundee DDI 4HN, Scotland | |
关键词: Insulin; Epidermal growth factor; ATP-citrate lyase; Acetyl-CoA carboxylase; Protein phosphorylation; EGF; epidermal growth factor; IGF-1; insulin-like growth factor-1; HPLC; high-performance liquid chromatography; PDGF; platelet-derived growth factor; | |
DOI : 10.1016/0014-5793(85)80282-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Insulin and EGF cause identical stimulation(≅40%) of fatty acid synthesis in hepatocytes isolated from rats which have been starved and then refed a low-fat diet. In both cases this stimulation is associated with increased phosphorylation of ATP-citrate lyase and of a specific site on acetyl-CoA carboxylase. However, the altered phosphorylation of acetyl-CoA carboxylase is not associated with a change in kinetic parameters which is detectable in the purified enzyme. Whatever the mechanism involved, stimulation of fatty acid synthesis by growth factors may have a role in providing new phospholipid for growth of membranes.
【 授权许可】
Unknown
【 预 览 】
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RO201912020286426ZK.pdf | 483KB | download |