Partial sequence homology of human myc oncogene protein to beta and gamma crystallins

FEBS Letters

Crabbe, M.James C.¹ 

[1] Nuffield Laboratory of Ophthalmology, Oxford University, Walton Street, Oxford OX2 6AW, England

关键词: Oncogene;    c-myc protein;    Crystallin;    Lens;   

DOI  :  10.1016/0014-5793(85)81133-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The human cellular myc gene is one of about 20 cellular oncogenes which code for a variety of proteins including protein kinases and growth factors [1]. The human gene is related to the avian myelocytomatosis leukaemia virus MC29 [2] and produces a binding protein which may be involved in regulation of gene expression [3] and cellular differentiation and proliferation [4]. The crystallins are proteins in the eye lens synthesised at different stages of cell differentiation and proliferation, and whose short range order is necessary for lens transparency [5,6]. Computer-based sequence comparisons show that beta Bp and gamma II crystallins, which show partial sequence homology and conservation of ‘Greek Key’ motives [7,8] are also partially homologous to two regions on the human myc protein, though this protein probably does not conserve the ‘Greek Key’ structural motives.

【 授权许可】

Unknown