Activation of yeast 6‐phosphofructo‐2‐kinase by protein kinase and phosphate

FEBS Letters

Hess, Benno¹  Yamashoji, Shiro¹ 

[1] Max-Planck-Institutfür Ernährungphysiologie, 4600 Dortmund 1, FRG

关键词: Yeast;    6-phosphofructo-2-kinase;    Protein kinase;    Phosphatase;    PFK1;    6-phosphofructo-1-kinase;    PFK2;    6-phosphofructo-2-kinase;    FBPasel;    fructose-1;    6-bis-phosphatase;    FBPase2;    fructose-2;    6-bisphosphatase;    F6P;    fructose 6-phosphate;    F16P;    fructose 1;    6-bisphosphate;    F26P;    fructose 2;    6-bisphosphate;    PEP;    phospho-enolpyruvate;    cAMP;    cyclic AMP;    PMSF;    phenylme-thanesulfonyl fluoride;    DTT;    dithiothreitol;    2-ME;    2-mercaptoethanol;    Mes;    4-morpholineethanesulfonate;   

DOI  :  10.1016/0014-5793(84)80611-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

6-phosphofructo-2-kinase (PFK2) is activated by a cAMP-dependent protein kinase, and inactivated by phosphatase, indicating the interconversion of PFK2. Inorganic phosphate also activates PFK2, and the optimum pH for the PFK2 activity varies with the concentration of phosphate. Phosphate also enhances the inactivation of PFK2 by citrate, suggesting that phosphate acts as a regulator of PFK2.

【 授权许可】

Unknown