Involvement of protein HMG1 in DNA replication

FEBS Letters

Marekov, Lyuben N.¹  Alexandrova, Evdokia A.¹  Beltchev, Beltcho G.¹ 

[1] Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria

关键词: High mobility group protein 1;    Antibody;    DNA replication;    Ehrlich ascites cell nucleus;    HMG;    high mobility group;    NEM;    N-ethylmaleimide;    ddTTP;    2';    3'-dideoxythymidine-5'-triphosphate;   

DOI  :  10.1016/0014-5793(84)81260-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Antibodies against HMG1 inhibit the incorporation of [³H]thymidine in Ehrlich ascites cell nuclei. By the use of specific inhibitors it is shown that HMG1 is needed for the action of the replicative DNA polymerase and not for the reparative one. This is supported by the fact that the addition of exogenous HMG1 to the nuclei enhances the replication process.

【 授权许可】

Unknown