Stimulatory effects of adenosine, adenosine analogs and insulin on adipose tissue lipoprotein lipase activity and their prevention by phosphodiesterase inhibitors

FEBS Letters

Bourdeaux, Anne-Marie¹  Nordmann, Roger¹  Giudicelli, Yves¹ 

[1] Service de Biochimie de la Faculté de Médecine Paris-Ouest et Groupe de Recherches U72 de l'INSERM, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France

关键词: Adipose tissue;    Insulin;    Adenosine;    Adenosine analog;    Lipoprotein lipase;    Cyclic AMP;    Phosphodiesterase;   

DOI  :  10.1016/0014-5793(84)81256-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Adenosine and its ‘R_i’- and ‘P’-site analogs, N ⁶-phenylisopropyladenosine and 2'-deoxyadenosine, stimulate, like insulin, lipoprotein lipase (LPL) activity in adipose tissue, an effect which is suppressed by cycloheximide. However, adenosine and its analogs do not potentiate the effects of submaximal insulin concentrations. As addition of cyclic AMP phosphodiesterase inhibitors abolishes the LPL stimulatory effects of insulin, adenosine and its analogs, this study suggests that these LPL effects are mediated through common mechanisms which are likely a decrease in cyclic AMP and an increase in LPL biosynthesis.

【 授权许可】

Unknown