Inhibition by Cu2+ of amphotericin B induced lysis of erythrocytes

FEBS Letters

Chéron, Monique¹  Brajtburg, Janina²  Bolard, Jacques¹ 

[1] Département de Recherches Physiques (LA CNRS No. 71), Université Pierre et Marie Curie, 4, Place Jussieu, 75230 Paris Cédex 05, France;Washington University School of Medicine, Division of Infectious Diseases, Department of Internal Medicine, Box 8051, 660 South Euclid Avenue, St. Louis, MO, USA

关键词: Polyene antibiotic;    Amphotericin B;    Hemolysis;    Erythrocyte;    Copper;   

DOI  :  10.1016/0014-5793(84)81255-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Amphotericin B-induced lysis of erythrocytes is diminished in the presence of Cu²⁺, but the prelytic amphotericin B-induced K⁺ leakage is unaffected. These results and the weak binding of Cu²⁺ to amphotericin B, demonstrated by circular dichroism and EPR studies, are consistent with the view that Cu²⁺ protects erythrocytes by increasing their resistance to lysis.

【 授权许可】

Unknown