Chemically induced antioxidant‐sensitive respiration

FEBS Letters

Videla, Luis A.¹ 

[1]Unidad de Bioquimica, Departamento de Ciencias Biologicas, Division de Ciencias Medicos Ocddente, Universidad de Chile, Casilla 10455 - Correo Central, Santiago, Chile

关键词: Antioxidant-sensitive respiration;    Glutathione;    Lipid peroxidation;    Malondialdehyde;    Perfused rat liver;   

DOI  :  10.1016/0014-5793(84)81253-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The interrelations between the hepatic chemically induced antioxidant-sensitive respiration and the contents of malondialdehyde (MDA) and of reduced glutathione (GSH), were studied in the isolated hemoglobin-free perfused rat liver. Antioxidant-sensitive respiration was induced by the infusion of agents such as ethanol, iron, xanthine or t-butyl hydroperoxide, or by phenylhydrazine pretreatment in vivo. The development of this respiratory component occurred concomitantly with high levels of MDA in the perfused livers, while those of GSH were diminished.

【 授权许可】

Unknown