Catecholamine control of enzymes involved in isocitrate oxidation of rat liver mitochondria

FEBS Letters

Kulinsky, Vladimir I.¹  Trufanova, Ludmila V.¹  Medvedev, Alexei E.¹ 

[1] Department of Biochemistry of Krasnoyarsk Medical Institute, 660022 Krasnoyarsk, USSR

关键词: Catecholamine;    Adrenoceptor;    Cyclic AMP;    Mitochondria;    NAD (P)+-dependent isocitrate dehydrogenase NAD(P)+-transhydrogenase;   

DOI  :  10.1016/0014-5793(84)80999-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Treatment of rats or liver homogenates with catecholamines (isoproterenol or noradrenaline) increased activities of both NAD⁺-dependent isocitrate dehydrogenase and NAD(P)⁺ -transhydrogenase (in the direction of hydrogen transfer NADPH → NAD⁺ with no change in NADP⁺ -dependent isocitrate dehydrogenase. These effects were realized via β-adrenoceptors. Cyclic AMP mimicked the catecholamine action on incubation with liver homogenate. The effects of catecholamines and cyclic AMP were not additive.

【 授权许可】

Unknown