Anti‐LPS factor in the horseshoe crab, Tachypleus tridentatus

FEBS Letters

Nakamura, Takanori²  Ohashi, Kunihiro¹  Niwa, Makoto¹  Iwanaga, Sadaaki²  Morita, Takashi² 

[1] Department of Biology, Faculty of Science, Kyushu University, Higashi-ku, Fukuoka 812, Japan;Department of Bacteriology, Osaka City University Medical School Abeno-ku, Osaka 545 Japan

关键词: Horseshoe crab;    Lipopolysaccharide;    Hemolysis;    Red blood cell;    LPS;    lipopolysaccharide;    RBC;    red blood cells;   

DOI  :  10.1016/0014-5793(84)80942-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Anti-LPS factor, which inhibits the endotoxin mediated coagulation system in the horseshoe crab, Tachypleus tridentatus, was found to lyse red blood cells sensitized with gram-negative bacterial LPS, but not to lyse unsensitized cells. This hemolysis occurred even at 0°C and was completed within 1 min. The binding of anti-LPS factor to LPS must be essential for the hemolysis, because free LPS inhibited the hemolytic action of anti-LPS factor.

【 授权许可】

Unknown