γ‐Hexachlorocyclohexane activation of alveolar macrophage phosphatidylinositol cycle, calcium mobilization and O− 2 production

FEBS Letters

Stickle, Douglas F.¹  Marchiarullo, Michael A.¹  Holian, Andrij¹ 

[1] Cardiovascular-Pulmonary Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA

关键词: Macrophage;    Hexachlorocyclohexane;    Phosphatidylinositol;    Qu2 Formyl peptide;    Calcium;   

DOI  :  10.1016/0014-5793(84)80930-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The influence of γ-hexachlorocyclohexane (HCC) on phosphatidyl inositol (PI) cycle activity was investigated in the guinea pig alveolar macrophage. Similar to stimulation by the chemotactic peptide N-formyl-nle-leu-phe (FNLLP), 125μM HCC was found to stimulate PI cycle activity, calcium mobilization (⁴⁵Ca²⁺ efflux and cytosolic [Ca²⁺] elevation) and O⁻ ₂ production, although the action of HCC was prolonged in comparison. HCC treatment did not block subsequent stimulation by FNLLP. HCC is proposed to act at an early stage in the same activation sequence as does FNLLP.

【 授权许可】

Unknown