Evidence that the insulin receptor‐associated protein kinase acts as a phosphatidylinositol kinase

FEBS Letters

Wieland, O.H.¹  Machicao, E.¹ 

[1] Institut für Klinische Chemie und Forschergruppe Diabetes, Städtisches Krankenhaus München-Schwabing, Kölner Platz 1, 8000 München 40, FRG

关键词: Insulin receptor;    Tyrosine kinase;    Signal transduction;    Phosphoinositide system;    Second messenger;   

DOI  :  10.1016/0014-5793(84)80581-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Insulin receptor preparations from human placenta at various states of purity were shown to catalyze insulin-stimulated phosphate incorporation from [γ-³²P]ATP into endogenous (membrane) and exogenous phosphatidylinositol. Our data suggest that the insulin receptor associated protein (tyrosine) kinase can act as a phosphatidylinsositol kinase, and that this mechanism may be of physiological importance in signal transduction of insulin.

【 授权许可】

Unknown