Inner and outer complexes of Pt‐coordination compounds with DNA probed by SERS spectroscopy

FEBS Letters

Koglin, E.¹  Séquaris, J.-M.¹  Malfoy, B.² 

[1] Institute of Applied Physical Chemistry, Nuclear Research Centre (KFA) Juelich, PO Box 1913, D-5170 Juelich, FRG;Centre de Biophysique Moléculaire, Avenue de la Recherche Scientifique, F-45045 Orléans Cédex, France

关键词: DNA-Pt complex;    Stereochemical configuration;    SERS spectroscopy;    Interfacial behavior;   

DOI  :  10.1016/0014-5793(84)81024-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Surface enhanced Raman scattering (SERS) spectroscopy has been used to study the interfacial behaviour of DNA modified by cis-Pt(NH₃)₂Cl₂, (cis-DDP) and [Pt-(dien)Cl]Cl bidentate and monodentate platinum coordination compounds, respectively. Two stereochemical configurations of Pt-DNA complexes can be deduced from the adsorption behaviour of the Pt adducts. The antitumoral inactive [Pt-(dien)Cl]Cl forms an outer complex whereas the antitumoral active cis-DDP favours an inner complex.

【 授权许可】

Unknown